Postdoctoral Research Fellow in epigenetics at the K.G Jebsen Centre of Obesity Research (CORA)

About the position

Applications are invited for a 3-year position as postdoctoral researcher in epigenetics and obesity research at the newly established K.G Jebsen Centre of Obesity ReseArch (CORA). The position will be affiliated to Yvonne Böttcher’s research group at the Department of Clinical Molecular Biology (EpiGen) at Institute of Clinical Medicine, UiO, physically located at Campus Ahus (Akershus University Hospital).

The project aims at investigating molecular mechanisms underlying weight regain and long-term weight loss maintenance using advanced molecular biology techniques. In particular, the project will investigate amongst other the concept of epigenetic memory of obesity in humans and closely collaborate with clinical environments involved in treatment of obesity

The applicant will be involved in tasks related to epigenetic and epitranscriptomic mechanisms potentially being implicated in the regulation of human body weight and adipose tissue biology in general. We are looking for a candidate with extensive hands-on training on a broad spectrum of multiomics analyses in adipose tissue. The applicant will join a team with long-standing experience in translational obesity research whilst other groups in the department Is generally working on translational biomedical research focusing on Alzheimer´s, and cancer research in a precision medicine perspective.

Project description

Obesity is a growing health problem worldwide. Metabolic surgery or use of GLP-1R analoga are efficient methods to induce significant weight loss in individuals with obesity. However, many individuals struggle to maintain a healthier body weight and often suffer from regain weight after treatment. The newly established K.G. Jebsen Center for obesity research (CORA), lead by Prof. Yvonne Böttcher, aims to understand the biological mechanisms underlying weight regain and obesity relapse, identify individuals at risk, and develop strategies for sustained weight loss and long-term weight maintenance.

Yvonne Böttcher’ research group (https://functionalgeneticsofobesity.wordpress.com/) is investigating the role of epigenetic mechanisms in obesity, the molecular mechanisms imposed by DNA, RNA and histone modifications and their potential interplay with genetic risk variants. In CORA, the group will specifically focus on the role of epigenetic memory in adipose tissue after weight loss.

The project aims at investigating mechanisms involved in metabolic memory in human adipose tissue and weight re-gain after weight loss in humans. The candidate will be closely involved in collaborations with excellent clinical environments in Norway and abroad.

The successful applicant will will work on amongst others on human biomaterial and cell culture models to better understand the potential epigenetic mechanisms responsible for weight regain. The work will include advanced molecular biology techniques such as next generation sequencing and multi-omics technologies as well as potentially single-cell technologies.

The position will require collaboration both within Norway, and internationally, with clinicians, molecular biologists and bioinformaticians/statisticians in other areas of the centre. The successful candidate is expected to become a driver of the project in close

Your areas of responsibility will be

Carry out high-quality scientific researchPublish results in high-impact, peer-reviewed scientific journalsApply for research funding Disseminate research at national and international meetings and conferences Co-Mentoring of PhD and mentoring of master students 

Qualifications and competence

Qualification requirements:

A degree equivalent to a Norwegian doctoral degree in molecular biology, biomedicine, genetics, or a closely related area. If the degree is not yet formally received, the doctoral dissertation must be submitted for evaluation by the application date. Only applicants with an approved doctoral thesis and public defense are eligible for employmentExperience in epigenetics and/or obesity research Extensive experience in molecular biology laboratory workHands-on experience in one or more of the following:
Single cell sequencing techniques Omics techniques such as ChIP-seq, CUT & Run; CUT & Tag, ATAC-seq, Whole genome bisulphite sequencing, RNAseq, Nanopore sequencing, ribosome profilingWork with human adipose tissue or primary adipocytes and relevant cell culture models such as 3T3L-1 adipocytes or SGBS cells Next generation sequencing data analysis 
Excellent written and oral communication skills in EnglishPublished first author papers in well recognized journals

It is an advantage if you have:

Experience working with sensitive data in TSD  Methodologal knowledge in cell sorting Basic programming skills (R/Python/Unix) Competence in statistics (R/SPSS/Stata) 

Personal characteristics

Team playerSelf-driven/ independent  Structured and well organized Good communication and collaboration skills Positive and enthusiastic 
 

Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications.

We need different perspectives in our work

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no.

We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues—could you be the next one?

We will provide appropriate accommodations should you need them. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.

If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian).

The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports.

More information about gender equality initiatives at UiO can be found here.

We hope you will apply for the position with us.

We can offer you

A stimulating environment at a high scientific level at CORA, with possibilities for extensive cross-diciplinary collaborationsExcellent laboratory facilities at EpiGen Career development programs through the Postdoctoral programme (The Medical Faculty, UiO), and through the K.G. Jebsen academy for young scientists Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal developmentGood welfare schemes.Opportunity of up to 1.5 hours a week of exercise during working hours.A workplace with good development and career opportunities.Membership in the Statens Pensjonskasse, which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemesSalary in position as Postdoctoral Fellow, position code 1352 in salary range NOK from 595 00 to 679 000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund

Read more about the benefits of working in the public sector at Employer Portal

Application

Your application should include:

Application letterCVA complete list of publications separating original publications from review articlesTranscripts and certificatesContact information for 2-3 references

Your CV must be entered in Jobbnorge’s CV form and cannot be submitted only as an attachment. This requirement is intended to ensure correct documentation and record-keeping in accordance with the Public Administration Act, Section 15.

Application with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for this job".

When applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language.

General information

Please note that we are unable to add documentation after the application deadline. As the deadline applies equally to all applicants, this policy ensures equal treatment throughout the recruitment process. If you experience difficulties uploading documents in Jobbnorge, please contact their customer service: Phone: +[phone] or Email: [email protected] 

The primary method of communication throughout the process will be e-mails and messages through the recruitment system Jobbnorge. When you receive a notification of a message in Jobbnorge, please log in to read it, as it may be important.

The best qualified candidates will invited for interviews.

No one can be appointed for more than one Postdoctoral Research Fellowship at the University of Oslo.

Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we cannot, you will hear from us.

Please refer to Regulations for the Act on universities and colleges chapter 3 (Norwegian) and Guidelines concerning appointment to recruitment positions at UiO.

The University of Oslo has a transfer agreement with all employees to secure the rights to all research results and related intellectual property.